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Merck

C-113

Supelco

Cortisol-D4 (9,11,12, 12-D4) solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Synonim(y):

Cortisol-D4 (9,11,12,12-D4) solution, Hydrocortisone-9,11,12,12-D4 solution

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About This Item

Wzór empiryczny (zapis Hilla):
C21H26D4O5
Numer CAS:
Masa cząsteczkowa:
366.48
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.24

klasa czystości

certified reference material

Poziom jakości

Postać

liquid

Właściwości

Snap-N-Spike®/Snap-N-Shoot®

opakowanie

ampule of 1 mL

producent / nazwa handlowa

Cerilliant®

stężenie

100 μg/mL in methanol

metody

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Zastosowanie

clinical testing
clinical testing

format

single component solution

temp. przechowywania

−20°C

ciąg SMILES

[2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D

Klucz InChI

JYGXADMDTFJGBT-BJJKTIQHSA-N

Opis ogólny

Cortisol-D4 (9,11,12, 12-D4) is the deuterated form of the glucocorticoid, cortisol. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing’s syndrome, Addison’s disease, and Sheehan’s syndrome.

Zastosowanie

This Certified Spiking Solution® is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports testing.The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:
  • Identification of cortisol by atmospheric pressure chemical ionization (APCI) and selected reaction monitoring (SRM) during the high-performance liquid chromatography- tandem mass spectrometric (HPLC-MS/MS) analysis of cortisol in human sweat samples
  • Combined determination of cortisol and cortisone in 48 serum samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS)
  • Development and validation of an LC-MS/MS method to determine five steroids― free cortisol, cortisone, tetrahydrocortisol, allo-tetrahydrocortisol, and tetrahydrocortisone in urine samples
  • Multi-residue analysis of cortisol, cortisone, and dehydroepiandrosterone sulfate (DHEAS) in 103 hair samples by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-MS/MS)
  • Rapid LC-MS/MS-based assay of cortisol in 2860 serum samples over a duration of one year, using a simple protein precipitation technique for sample preparation

Cechy i korzyści

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Informacje prawne

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

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Klasyfikacja zagrożeń

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Kod klasy składowania

3 - Flammable liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

49.5 °F - closed cup

Temperatura zapłonu (°C)

9.7 °C - closed cup


Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Helen V Ratajczak et al.
Future science OA, 1(4), FSO70-FSO70 (2016-12-30)
Measure biomarkers pertinent to autism in saliva from humans. At 7:30 PM (reading instructions) and 8:30 PM (hearing instructions), neurotypical adults (6 M, 6 F) each spat into tubes containing protease inhibitors. Cells were counted, samples aliquoted, frozen and thawed.

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