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D-062

Supelco

21-Deoxycortisol solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Wzór empiryczny (zapis Hilla):
C21H30O4
Numer CAS:
641-77-0
Masa cząsteczkowa:
346.46
Numer WE:
200-659-6
Numer MDL:
MFCD00056476
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329798625
NACRES:
NA.24

klasa czystości

certified reference material

Poziom jakości

300

Postać

liquid

Właściwości

Snap-N-Spike®/Snap-N-Shoot®

opakowanie

ampule of 1 mL

producent / nazwa handlowa

Cerilliant®

stężenie

100 μg/mL in methanol

metody

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Zastosowanie

clinical testing
clinical testing

format

single component solution

temp. przechowywania

−20°C

ciąg SMILES

CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C

InChI

1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1

Klucz InChI

LCZBQMKVFQNSJR-UJPCIWJBSA-N

Opis ogólny

A new calibration material suitable for LC/MS applications in clinical and diagnostic testing and endocrinology. 21-deoxycortisol, a steroid intermediate in the formation of cortisol, is measured in whole blood or serum by LC/MS for newborn screening of congenital adrenal hyperplasia (CAH) and other adrenal diseases.

Zastosowanie

  • Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography-tandem mass spectrometry: This article emphasizes the significance of steroid profiling using advanced chromatography techniques to diagnose congenital adrenal hyperplasia, highlighting the role of 21-Deoxycortisol as a critical marker (Feng D et al., 2023).
  • Second-tier Testing for 21-Hydroxylase Deficiency in the Netherlands: A Newborn Screening Pilot Study: This study introduces a second-tier testing protocol involving 21-Deoxycortisol to enhance the screening process for congenital adrenal hyperplasia in newborns, demonstrating its utility in early and accurate diagnosis (Stroek K et al., 2021).

Informacje prawne

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

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Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H225,H301 + H311 + H331,H370

Klasyfikacja zagrożeń

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Organy docelowe

Eyes

Kod klasy składowania

3 - Flammable liquids

Klasa zagrożenia wodnego (WGK)

WGK 1

Temperatura zapłonu (°F)

49.5 °F - closed cup

Temperatura zapłonu (°C)

9.7 °C - closed cup

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

A Milewicz et al.
Endokrynologia Polska, 44(2), 187-193 (1993-01-01)
The study was aimed at evaluation of usefulness of determination of blood serum 21-deoxycortisol concentration for the detection of heterozygous carriers of incomplete block of 21-hydroxylase synthesis leading to adrenal hyperplasia. An earlier observation of the authors that the determination
[21-Deoxycortisol].
Y Okatani
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 2, 444-447 (1995-03-01)
H Blanché et al.
Human genetics, 101(1), 56-60 (1998-01-07)
21-hydroxylase (21-OH) deficiency accounts for the vast majority of nonclassic (NC) forms of congenital adrenal hyperplasia (CAH), and is associated with symptoms detectable either in childhood (precocious puberty) or sometimes only later in adulthood (hirsutism, acne, amenorrhea). While the severe
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(1), 77-82 (2003-12-23)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mainly caused by 21-hydroxylase deficit (21-OHD). Deletions or mutations of the CYP21 gene induce the impairment of glucocorticoid and mineralcorticoid synthesis. 17-Hydroxyprogesterone (17-OHP) is the hormonal marker in patients, but not
N S Sieber-Ruckstuhl et al.
The Veterinary record, 162(21), 673-678 (2008-05-27)
The serum concentrations of cortisol, 17alpha-hydroxypregnenolone, 17alpha-hydroxyprogesterone, 21-deoxycortisol and 11-deoxycortisol were measured in 19 healthy dogs, 15 dogs with pituitary-dependent hypercortisolism (pdh) and eight dogs with other diseases before and one hour after an injection of synthetic adrenocorticotrophic hormone (acth).
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