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860658P

Avanti

sphinganine-d7

Avanti Research™ - A Croda Brand 860658P, powder

Synonim(y):

D-erythro-sphinganine-d7

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About This Item

Wzór empiryczny (zapis Hilla):
C18H32D7NO2
Numer CAS:
1246304-35-7
Masa cząsteczkowa:
308.55
Numer MDL:
MFCD34603140
Kod UNSPSC:
12352211
NACRES:
NA.25

Formularz

powder

opakowanie

pkg of 1 × 1 mg (860658P-1mg)

producent / nazwa handlowa

Avanti Research™ - A Croda Brand 860658P

Warunki transportu

dry ice

temp. przechowywania

−20°C

ciąg SMILES

OC[C@@](N)([H])[C@@](O)([H])CCCCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

InChI

1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1/i1D3,2D2,3D2

Klucz InChI

OTKJDMGTUTTYMP-GEZFCKIXSA-N

Opis ogólny

Sphinganine-d7 is a deuterated derivative of sphinganine. Sphinganine, also called as dihydrosphingosine is a derivative of sphingosine. Sphinganines are produced in endoplasmic reticulum, by decarboxylating condensation of palmitoyl-CoA and serine.

Zastosowanie

Sphinganine-d7 has been used as an internal standard for quantification of sphingolipid concentrations in plasma and tissue samples by high-performance liquid chromatography tandem mass spectrometry.

Działania biochem./fizjol.

Sphinganine (SPA) acts as a selective inhibitor of protein kinase C in intact human neutrophils. It may function a potential biomarker for the diagnosis of sphingolipidoses. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

Opakowanie

5 mL Amber Glass Screw Cap Vial (860658P-1mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
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Kod klasy składowania

11 - Combustible Solids

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Certyfikaty analizy (CoA)

Lot/Batch Number

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Odwiedź Bibliotekę dokumentów

Federica Storti et al.
eLife, 8 (2019-03-14)
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (ABCA1), have been associated
Graham Brogden et al.
Biomolecules, 9(9) (2019-09-11)
Sphingolipids are an important group of lipids that play crucial roles in living cells, facilitating cell recognition, signal transduction and endocytosis. The concentration of sphingosine and some of its derivatives like sphinganine may serve as a biomarker for the diagnosis
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary

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