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Key Documents

800812C

Avanti

12:0 DG

1,2-dilauroyl-sn-glycerol, chloroform

Synonim(y):

1,2-didodecanoyl-sn-glycerol; DG(12:0/12:0/0:0); 110611

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About This Item

Wzór empiryczny (zapis Hilla):
C27H52O5
Numer CAS:
Masa cząsteczkowa:
456.70
Kod UNSPSC:
12352211
NACRES:
NA.25

Próba

>99% (TLC)

Postać

liquid

opakowanie

pkg of 2 × 4 mL (800812C-200mg)
pkg of 1 × 5 mL (800812C-10mg)

producent / nazwa handlowa

Avanti Research - A Croda Brand 800812C

stężenie

2 mg/mL (800812C-10mg)
25 mg/mL (800812C-200mg)

typ lipidu

neutral lipids
neutral glycerides

Warunki transportu

dry ice

temp. przechowywania

−20°C

InChI

1S/C27H52O5/c1-3-5-7-9-11-13-15-17-19-21-26(29)31-24-25(23-28)32-27(30)22-20-18-16-14-12-10-8-6-4-2/h25,28H,3-24H2,1-2H3/t25-/m0/s1

Klucz InChI

OQQOAWVKVDAJOI-VWLOTQADSA-N

Opis ogólny

sn-1,2-diacylglycerols comprise short saturated acyl side chains (C4-C10) and 12:0 DG is also called 1,2-dilauroyl-sn-glycerol.

Zastosowanie

12:0 DG may be used:
  • as an internal standard for spiking serum samples for liquid chromatography–mass spectrometry analysis.
  • as an internal standard for spiking RAW 264.7 cells for mass spectroscopy studies
  • as standard in reverse-phase liquid chromatography coupled mass spectrometer for lipidomics studies of human plasma and serum samples

Działania biochem./fizjol.

sn-1,2-Diacylglycerols are prime regulators of biological functions, especially in platelets. They also activate protein kinase C. 1,2-dilauroyl-sn-glycerol is a polymerization initiator used in the synthesis of (R)-3-((2-bromo-2-methylpropanoyl)oxy)propane-1,2-diyl didodecanoate (BMPD).

Opakowanie

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-10mg)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800812C-200mg)

Przechowywanie i stabilność

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Inne uwagi

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbonesHealth hazard

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

Klasyfikacja zagrożeń

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Organy docelowe

Central nervous system, Liver,Kidney

Kod klasy składowania

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

does not flash

Temperatura zapłonu (°C)

does not flash


Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Lipid Profile Characterization and Lipoprotein Comparison of Extracellular Vesicles from Human Plasma and Serum
Sun Y, et al.
Metabolites, 9(11), 259-259 (2019)
Felicitas S Boretti et al.
Metabolomics : Official journal of the Metabolomic Society, 16(1), 1-1 (2019-12-05)
Food and dietary ingredients have significant effects on metabolism and health. To evaluate whether and how different diets affected the serum lipidomic profile of dogs. Sixteen healthy beagles were fed a commercial dry diet for 3 months (control diet). After an
Serum lipidome analysis of healthy beagle dogs receiving different diets
Boretti FS, et al.
Metabolomics, 16(1), 1-1 (2020)
Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm
Callender HL, et al.
Analytical Chemistry, 79(1), 263-272 (2007)
Li Yang et al.
Analytical and bioanalytical chemistry, 412(10), 2225-2235 (2020-01-07)
A novel online two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography-triple-quadrupole mass spectrometry (2D SFC/RPLC-QQQ MS) method based on a vacuum solvent evaporation interface was developed for lipid profiling in human plasma, in which lipid classes were separated by the first-dimension SFC

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