929441

C5-Pomalidomide-piperazine hydrochloride

≥95%

• Synonim(y): 2-(2,6-Dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₇H₁₈N₄O₄ · xHCl
• Numer CAS: 2228029-82-9
• Masa cząsteczkowa: 342.35 (free base basis)
• Numer MDL: MFCD34183126
• Kod UNSPSC: 12352101
• NACRES: NA.21

Właściwości

• ligand: pomalidomide
• Poziom jakości: 100
• Próba: ≥95%
• Postać: powder
• temp. przechowywania: 2-8°C
• ciąg SMILES: O=C1N(C2CCC(NC2=O)=O)C(C3=CC=C(N4CCNCC4)C=C31)=O

Opis

Zastosowanie

Protein degrader building block C₅-Pomalidomide-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a nitroveratryloxycarbonyl group that can undergo photolysis to form a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Block

Inne uwagi

Targeted Protein Degradation by Small Molecules

. Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informacje prawne

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H360D
• Zwroty wskazujące środki ostrożności: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Klasyfikacja zagrożeń: Repr. 1B
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable