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910007
20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid
95%
Synonim(y):
Azido-PEG6-CH2CO2H, Azido-PEG6-acid, N3-PEG6-CH2COOH
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About This Item
Wzór empiryczny (zapis Hilla):
C14H27N3O8
Numer CAS:
Masa cząsteczkowa:
365.38
Kod UNSPSC:
12352106
Polecane produkty
Próba
95%
Postać
(Liquid or Semi-Solid or Paste or Solid)
przydatność reakcji
reaction type: click chemistry
reagent type: cross-linking reagent
grupa funkcyjna
azide
carboxylic acid
temp. przechowywania
2-8°C
ciąg SMILES
OC(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O
Zastosowanie
This heterobifunctional, PEGylated crosslinker 20-Azido-3,6,9,12,15,18-hexaoxaicosanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG6-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Informacje prawne
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
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produkt powiązany
Numer produktu
Opis
Cennik
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Currently, there is mounting evidence that intermolecular receptor-receptor interactions may result in altered receptor recognition, pharmacology and signaling. Heterobivalent ligands have been proven useful as molecular probes for confirming and targeting heteromeric receptors. This report describes the design and synthesis
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