907308

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol

≥95%

• Synonim(y): Hydroxyl diazirine difluoro TIPS-alkyne, MI-PAL, Minimally interfering photoaffinity label, Photo-click tag, Probe building block
• Wzór empiryczny (zapis Hilla): C₁₄H₂₄F₂N₂OSi
• Numer CAS: 2227014-08-4
• Masa cząsteczkowa: 302.44
• Numer MDL: MFCD32667402
• Kod UNSPSC: 12352200

Właściwości

• Próba: ≥95%
• Formularz: liquid
• dostępność: available only in USA
• temp. przechowywania: −20°C
• ciąg SMILES: [Si](C(C)C)(C(C)C)(C(C)C)C#CC(F)(F)C1(N=N1)CO
• InChI: 1S/C14H24F2N2OSi/c1-10(2)20(11(3)4,12(5)6)8-7-13(15,16)14(9-19)17-18-14/h10-12,19H,9H2,1-6H3
• Klucz InChI: SKAPASYQQQYNJK-UHFFFAOYSA-N

Opis

Zastosowanie

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol is a minimally interfering photo-affinity label (MI-PAL). Photoaffinity labeling is of growing interest in chemical biology and drug discovery research to characterize the non-covalent interactome and is used in protein profiling; the study of protein-protein interactions and complexes; and target engagement, identification, or validation studies. This MI-PAL contains a diazirine for UV light-induced (∼365 nm) covalent modification of a biological target with potential for downstream applications via the click chemistry-enabling alkyne tag. Its small size exhibits minimal perturbation of the interactions between proteins and the ligand or probe. The Woo lab demonstrated the electronic tuning of this MI-PAL with the placement of stability-imparting fluorine groups adjacent to the diazirine and alkyne. The alkyl fluorine ion losses are also a useful marker in collision-induced dissociation (CID) mass spectrometry experiments. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Inne uwagi

Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small moleculeeprotein interactions

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H242
• Zwroty wskazujące środki ostrożności: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Klasyfikacja zagrożeń: Self-react. C
• Kod klasy składowania: 5.2 - Organic peroxides and self-reacting hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable