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162957
6-Hydroxydopamine hydrobromide
95% (HPLC), powder, neurotoxin
Synonim(y):
2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
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About This Item
Wzór liniowy:
(HO)3C6H2CH2CH2NH2 · HBr
Numer CAS:
Masa cząsteczkowa:
250.09
Beilstein:
3713280
Numer WE:
Numer MDL:
Kod UNSPSC:
12352116
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Nazwa produktu
6-Hydroxydopamine hydrobromide, 95%
Poziom jakości
Próba
95%
Formularz
powder
mp
216-220 °C (lit.)
temp. przechowywania
−20°C
ciąg SMILES
Br.NCCc1cc(O)c(O)cc1O
InChI
1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
Klucz InChI
MLACDGUOKDOLGC-UHFFFAOYSA-N
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Opis ogólny
Solutions should be freshly prepared and protected from exposure to light.
Zastosowanie
6-Hydroxydopamine hydrobromide has been used:
- to induce Parkinson′s disease (PD) in mouse models to study the effects of tubastatin A (TBA) on nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) activation and cell injury in SH-SY5Y cells
- to induce pharmacological ablation of the sympathetic nerves to study the effect of hepatic sympathetic nerve activity (SNA) on hepatic steatosis during diet-induced obesity in mice
- to induce oxidative stress in mesencephalic cells to study its effect on p75NTR signaling in neuronal cells of the ventral mesencephalon
Działania biochem./fizjol.
6-Hydroxydopamine hydrobromide (6-OHDA) is a neurotoxin that elicits oxidative damage and destroys catecholaminergic or sympathetic terminals. It is commonly used to induce Parkinson′s disease in the experimental model. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organy docelowe
Respiratory system
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Środki ochrony indywidualnej
dust mask type N95 (US), Eyeshields, Gloves
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