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주요 문서

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1368008

USP

Liothyronine

United States Pharmacopeia (USP) Reference Standard

동의어(들):

3,3′,5-Triiodo-L-thyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3

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About This Item

실험식(Hill 표기법):
C15H12I3NO4
CAS Number:
6893-02-3
Molecular Weight:
650.97
Beilstein:
2710227
MDL number:
MFCD00002593
UNSPSC 코드:
41116107
PubChem Substance ID:
329750059
NACRES:
NA.24

Grade

pharmaceutical primary standard

API family

liothyronine

제조업체/상표

USP

mp

234-238 °C (lit.)

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-8°C

SMILES string

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChI key

AUYYCJSJGJYCDS-LBPRGKRZSA-N

유전자 정보

human ... THRA(7067) , THRB(7068)

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일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Liothyronine USP reference standard for use in specified quality tests and assays.

Also used to prepare standard, standard stock, Liothyronine stock, and resolution solutions for assay, and identification test according to given below monographs of the United States Pharmacopeia (USP):
  • Thyroid
  • Levothyroxine Sodium Tablets
  • Liothyronine Sodium Tablets

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H372

예방조치 성명서

P260 - P264 - P270 - P314 - P501

Hazard Classifications

STOT RE 1

표적 기관

Thyroid,Cardio-vascular system,Kidney

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Liothyronine Sodium Tablets
United States Pharmacopeia, 34(4), 2640-2640 (2013)
Sara Santos Bernardes et al.
Cell and tissue research, 357(3), 803-814 (2014-05-21)
The role of reactive oxygen species (ROS) in muscle protein hydrolysis and protein oxidation in thyrotoxicosis has not been explored. This study indicates that ROS play a role in skeletal muscle wasting pathways in thyrotoxicosis. Two experimental groups (rats) were
Akihiro Mouri et al.
Psychoneuroendocrinology, 48, 147-161 (2014-07-13)
Attention deficit/hyperactivity disorder (ADHD) has been reported in association with resistance to thyroid hormone, a disease caused by a mutation in the thyroid hormone receptor β (TRβ) gene. TRβ is a key protein mediating down-regulation of thyrotropin (TSH) expression by
Héctor F Escobar-Morreale et al.
The Journal of clinical endocrinology and metabolism, 90(8), 4946-4954 (2005-06-02)
Combined infusion of levothyroxine plus liothyronine, as opposed to levothyroxine alone, is the only way of restoring the concentrations of circulating TSH, T4, and T3 as well as those of both T4 and T3 in all tissues of thyroidectomized rats.
Erica Sarchielli et al.
Experimental neurology, 257, 130-147 (2014-05-06)
Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the
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