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Merck
모든 사진(4)

Key Documents

T7650

Sigma-Aldrich

3,3′,5-Triiodothyroacetic acid

≥90%

동의어(들):

4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylacetic acid

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About This Item

실험식(Hill 표기법):
C14H9I3O4
CAS Number:
Molecular Weight:
621.93
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:

Quality Level

분석

≥90%

형태

powder

저장 온도

−20°C

SMILES string

OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1

InChI

1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)

InChI key

UOWZUVNAGUAEQC-UHFFFAOYSA-N

유전자 정보

관련 카테고리

애플리케이션


  • Thyroid hormone research: A study explored the impact of 3,3′,5-Triiodothyroacetic acid on peripheral and neurodevelopmental findings in patients with MCT8 deficiency, highlighting its potential in therapeutic interventions for thyroid-related developmental disorders (Unsal and Hayran, 2024).

  • Neurological disorder management: Research demonstrated the use of 3,3′,5-Triiodothyroacetic acid in addressing impaired T3 uptake and action in cerebral organoids modeling Allan-Herndon-Dudley syndrome, providing insights into its application in managing brain-specific thyroid hormone transport abnormalities (Salas-Lucia et al., 2024).

  • Pharmaceutical development for antiviral therapies: Tiratricol, a derivative of 3,3′,5-Triiodothyroacetic acid, was identified as an inhibitor of yellow fever virus replication by targeting the viral RNA-dependent RNA polymerase, showcasing its potential in antiviral drug development (Ren et al., 2023).

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3


시험 성적서(COA)

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문서 라이브러리 방문

Rie Anzai et al.
Thyroid : official journal of the American Thyroid Association, 22(10), 1069-1075 (2012-09-06)
The effectiveness of short-term 3,5,3'-triiodothyroacetic acid (TRIAC) therapy for the treatment of hyperthyroidism caused by thyroid hormone resistance (RTH) has been documented. Here, we report a 3-year course of TRIAC therapy in an RTH boy, with a quantitative evaluation of
Napoleão F Valadares et al.
Bioorganic & medicinal chemistry, 15(13), 4609-4617 (2007-05-01)
2D QSAR studies were carried out for a series of 55 ligands for the Thyroid receptors, TRalpha and TRbeta. Significant cross-validated correlation coefficients (q(2)=0.781 (TRalpha) and 0.693 (TRbeta)) were obtained. The models' predictive abilities were proved more valuable than the
Christopher J Ryerson et al.
Journal of pain and symptom management, 43(4), 771-782 (2012-01-31)
Little is known about the treatment and correlates of dyspnea in idiopathic pulmonary fibrosis (IPF). The objective of this systematic review was to summarize the literature regarding the treatment and correlates of dyspnea in IPF. MEDLINE, EMBASE, and all Evidence-Based
Debora Lucia Seguro Danilovic et al.
Thyroid : official journal of the American Thyroid Association, 18(6), 655-657 (2008-06-27)
Mesotherapy consists of cutaneous injections of a mixture of compounds and has recently been used for cosmetic purposes to reduce local fat and cellulite. To date, several reports have described only local adverse events related to this therapy. We describe
Warren J L Wood et al.
Chembiochem : a European journal of chemical biology, 10(2), 361-365 (2008-12-24)
3-Iodothyronamine (T(1)AM) and 3,3',5-triiodothyroacetic acid (Triac) are bioactive metabolites of the hormone thyroxine (T(4)). In the present study, the ability of T(1)AM and 3,3',5-triiodothyronamine (T(3)AM) to be metabolized to 3-iodothyroacetic acid (TA(1)) and Triac, respectively, was investigated. Both T(1)AM and

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