T5516

3,3′,5-Triiodo-L-thyronine sodium salt

γ-irradiated, powder, suitable for, suitable for cell culture

• 동의어(들): Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• 실험식(Hill 표기법): C₁₅H₁₁I₃NNaO₄
• CAS Number: 55-06-1
• Molecular Weight: 672.96
• Beilstein: 8179867
• EC Number: 200-223-5
• MDL number: MFCD00002594
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24900290
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 무균: γ-irradiated
• 분석: ≥90% (HPLC)
• 형태: powder
• 기술: cell culture | mammalian: suitable
• 적합성: suitable for
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• InChI key: SBXXSUDPJJJJLC-YDALLXLXSA-M
• 유전자 정보: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

설명

일반 설명

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

애플리케이션

3,3′,5-Triiodo-L-thyronine sodium salt has been used:

• as a supplement in colon organ culture media
• to stimulate HuH-7 cells for analysing the hormonal influence on MBL synthesis
• to study its effect on human growth hormone (GH) versus mouse GH expression in the presence of ′′intact′′ GH genes and in a common pituitary cell context

생화학적/생리학적 작용

3,3′,5′-Triiodo-L-thyronine (T3) is a thyroid hormone that increases rates of proteins synthesis, stimulates the breakdown of cholesterol, and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

물리적 형태

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

제조 메모

Package size based on 3,3′,5-Triiodo-L-thyronine sodium salt content; vial may also contain inert salts, such as sodium chloride

재구성

To prepare 20 μg/ml stock solution: add 1 ml 1 N NaOH; gently swirl to dissolve; add 49 ml sterile medium.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)