1365000

Levothyroxine

United States Pharmacopeia (USP) Reference Standard

• 동의어(들): L-Thyroxine, 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Linear Formula: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• CAS Number: 51-48-9
• Molecular Weight: 776.87
• Beilstein: 2228515
• MDL number: MFCD00002595
• UNSPSC 코드: 41116107
• PubChem Substance ID: 329750052
• NACRES: NA.24

속성

• Grade: pharmaceutical primary standard
• API family: levothyroxine
• 제조업체/상표: USP
• mp: 223 °C (dec.) (lit.)
• 응용 분야: pharmaceutical (small molecule)
• 형식: neat
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• InChI key: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• 유전자 정보: human ... THRA(7067) , THRB(7068)

설명

일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Levothyroxine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Levothyroxine Sodium
• Levothyroxine Sodium Tablets
• Levothyroxine Sodium Oral Powder
• Liothyronine Sodium
• Thyroid
• Thyroid Tablets
• Liothyronine Sodium Tablets

생화학적/생리학적 작용

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

분석 메모

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

기타 정보

Sales restrictions may apply.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H372
• 예방조치 성명서: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• 표적 기관: Thyroid,Cardio-vascular system,Kidney
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable