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由来生物
rat
品質水準
リコンビナント
expressed in E. coli
フォーム
solution
分子量
~110 kDa
UniProtアクセッション番号
アプリケーション
cell analysis
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
rat ... Wee1(308937)
アプリケーション
Wee1, active from rat may be used to study apoptotic signaling.
生物化学的／生理学的作用
Wee1 is a protein tyrosine kinase that phosphorylates Cdc2 on Tyr15 and hence inactivates the CDK1 and CDK2, which facilitates in the negative regulation of entry of cells into mitosis. Increased level of wee1 stimulates Human Immunodeficiency Virus type 1 (HIV-1) Vpr induced cell cycle arrest at G2/M transition followed by apoptosis.
Protein inhibitor of Cdk2 kinase
単位の定義
One unit of Wee 1 is defined as the amount of Wee 1 which inhibits 90% of the activity of 10 units of Cdk2
物理的形状
Solution in 50 mM Tris-HCl, pH 7.5, 1 mM EDTA, 1 mM DTT, 10% Glycerol
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
最新バージョンのいずれかを選択してください：
P Russell et al.
Cell, 49(4), 559-567 (1987-05-22)
Fission yeast wee1- mutants initiate mitosis at half the cell size of wild type. The wee1+ activity is required to prevent lethal premature mitosis in cells that overproduce the mitotic inducer cdc25+. This lethal phenotype was used to clone wee1+
F S Goes et al.
European journal of biochemistry, 268(8), 2281-2289 (2001-04-12)
The Wee1 protein kinase negatively regulates entry into mitosis by mediating the inhibitory tyrosine phosphorylation of Cdc2-cyclin B kinase. The stability and activity of Wee1 from the fission yeast Schizosaccharomyces pombe is critically dependent on functional Hsp90 chaperones. Here we
Huidong Yuan et al.
Journal of virology, 78(15), 8183-8190 (2004-07-16)
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G(2)/M transition and subsequently apoptosis. Here we examined the potential involvement of Wee-1 in Vpr-induced G(2) arrest. Wee-1 is a cellular protein kinase that inhibits Cdc2 activity
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