V5765

Vascular Endothelial Growth Factor 165 human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• product name: VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture
• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in HEK 293 cells
• 詳細: Vascular Endothelial Growth Factor 165 human
• アッセイ: ≥95% (SDS-PAGE)
• 形状: lyophilized powder
• 有効性: <10 ng/mL ED₅₀
• 品質: endotoxin tested
• 分子量: dimer 42 kDa (glycosylated)
• 包装: pkg of 10 μg; pkg of 50 μg
• テクニック: cell culture | mammalian: suitable
• 不純物: <0.075 EU/μg
• 色: white
• 溶解性: water: soluble
• UniProtアクセッション番号: P15692
• 保管温度: −20°C
• 遺伝子情報: human ... VEGFA(7422)

詳細

詳細

VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

生物化学的／生理学的作用

VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).

アナリシスノート

特異的活性は、HUVEC細胞(ヒト臍帯静脈内皮細胞)の増殖の用量依存的な刺激作用によって確認されています。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable