V3639

バリノマイシン

Ready Made Solution, ~1 mg/mL in DMSO

• 別名: シクロ(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-ヒドロキシイソ吉草酸, Lac = 乳酸
• 実験式（ヒル表記法）: C₅₄H₉₀N₆O₁₈
• CAS番号: 2001-95-8
• 分子量: 1111.32
• Beilstein: 78657
• MDL番号: MFCD00005114
• UNSPSCコード: 51102829
• PubChem Substance ID: 24900743
• NACRES: NA.76

特性

• 由来生物: Streptomyces sp.
• 品質水準: 200
• アッセイ: ≥90% (HPLC)
• 形状: liquid
• 保管条件: (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
• 濃度: ~1 mg/mL in DMSO
• 色: colorless
• 抗生物質活性スペクトル: Gram-positive bacteria; parasites; viruses
• 作用機序: cell membrane | interferes
• 輸送温度: wet ice
• 保管温度: 2-8°C
• SMILES記法: CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• InChI Key: FCFNRCROJUBPLU-RPUZOQEISA-N

詳細

詳細

Chemical structure: peptide

アプリケーション

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

生物化学的／生理学的作用

K⁺選択的イオノフォア型環状デプシペプチドです。酸化的リン酸化を脱供役するカリウムイオノフォアです。ネズミ胸腺細胞においてアポト-シスを誘導します。NGF誘導性神経細胞分化を阻害し、ET誘導性血管収縮と拮抗します。

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

その他情報

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup
• 引火点(℃): 87 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter