V2013

[deamino-Cys¹, Val⁴, D-Arg⁸]-Vasopressin

≥95%

• 別名: Val⁴−dDAVP
• 実験式（ヒル表記法）: C₄₆H₆₅N₁₃O₁₁S₂
• 分子量: 1040.22
• MDL番号: MFCD00080166
• UNSPSCコード: 51111800
• PubChem Substance ID: 329829030
• NACRES: NA.32

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• 無菌性: non-sterile
• アッセイ: ≥95%
• フォーム: powder
• 溶解性: 50% acetic acid: soluble 1 mg/mL, clear, colorless
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N4CCC[C@H]4C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O
• InChI: 1S/C46H65N13O11S2/c1-25(2)38-44(69)56-32(22-35(47)61)41(66)57-33(45(70)59-18-7-11-34(59)43(68)54-29(10-6-17-51-46(49)50)39(64)52-23-36(48)62)24-72-71-19-16-37(63)53-30(21-27-12-14-28(60)15-13-27)40(65)55-31(42(67)58-38)20-26-8-4-3-5-9-26/h3-5,8-9,12-15,25,29-34,38,60H,6-7,10-11,16-24H2,1-2H3,(H2,47,61)(H2,48,62)(H,52,64)(H,53,63)(H,54,68)(H,55,65)(H,56,69)(H,57,66)(H,58,67)(H4,49,50,51)/t29-,30+,31+,32+,33+,34+,38+/m1/s1
• InChI Key: KEBRFHAVFOSSOX-WSFLLCRESA-N
• 遺伝子情報: human ... AVPR2(554) ; mouse ... AVPR2(12000) ; rat ... AVPR2(25108)

詳細

Amino Acid Sequence

Mpa-Tyr-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2

アプリケーション

[Deamino-Cys1, Val4, D-Arg8]-Vasopressin was used to prepare sample for qualitative detection of desmopressin in plasma by using liquid chromatography-electrospray tandem mass spectrometry.

生物化学的／生理学的作用

[Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin is a V1 antagonist that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.It can also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.

調製ノート

[deamino-Cys1, Val4, D-Arg8]-Vasopressin dissolves in water at 1 mg/ml to yield a clear, colorless solution.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)