T104

トロピセトロン 一塩酸塩

solid, ≥98% (HPLC)

• 別名: 1H-インドール-3-カルボン酸 (3-endo)-8-メチル-8-アザビシクロ[3.2.1]オクタ-3-イル エステル 一塩酸塩, 3-トロパニルインドール-3-カルボン酸 一塩酸塩, ICS-205,930, ナボバン
• 実験式（ヒル表記法）: C₁₇H₂₀N₂O₂ · HCl
• CAS番号: 105826-92-4
• 分子量: 320.81
• MDL番号: MFCD00210221
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278133
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: solid
• 溶解性: H₂O: >10 mg/mL
• オーガナイザー: Novartis
• 保管温度: 2-8°C
• SMILES記法: Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
• InChI: 1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
• InChI Key: XIEGSJAEZIGKSA-UHFFFAOYSA-N
• 遺伝子情報: human ... CHRNA3(1136) , CHRNA4(1137) , CHRNB2(1141) , CHRNB4(1143) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) ; rat ... Chrna7(25302) , Drd2(24318) , Htr1a(24473) , Htr3a(79246)

詳細

アプリケーション

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

生物化学的／生理学的作用

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

3-トロパニルインド-ル-3-カルボン酸塩酸塩は、5-HT₃セロトニンレセプタ-の選択的アンタゴニストです。

特徴および利点

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)