T0667

トリメトプリム 乳酸塩

≥98%

• 別名: 2,4-ジアミノ-5-(3,4,5-トリメトキシベンジル)ピリミジン 乳酸塩
• 実験式（ヒル表記法）: C₁₄H₁₈N₄O₃ · C₃H₆O₃
• CAS番号: 23256-42-0
• 分子量: 380.40
• EC Number: 245-533-1
• MDL番号: MFCD00171722
• UNSPSCコード: 51285203
• PubChem Substance ID: 329826610
• NACRES: NA.85

特性

• 品質水準: 200
• アッセイ: ≥98%
• 形状: powder
• 保管条件: (Keep container tightly closed in a dry and well-ventilated place.)
• 色: white
• 溶解性: H₂O: soluble 20 mg/mL
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• 作用機序: DNA synthesis | interferes; enzyme | inhibits
• 保管温度: 2-8°C
• SMILES記法: CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
• InChI: 1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
• InChI Key: IIZVTUWSIKTFKO-UHFFFAOYSA-N

詳細

詳細

Chemical structure: pyrimidine

アプリケーション

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

生物化学的／生理学的作用

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

その他情報

Keep container tightly closed in a dry and well-ventilated place.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H361d
• 注意書き: P202 - P264 - P280 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral - Repr. 2
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)