SRP8050

Profilin from Toxoplasma gondii

recombinant, expressed in E. coli, >95% (SDS-PAGE)

• 別名: Inflammatory profilin, T Cell Membrane Protein 1
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: Toxoplasma gondii
• リコンビナント: expressed in E. coli
• アッセイ: >95% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: ~20 kDa by SDS-PAGE
• 包装: pkg of 10 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: <0.01 EU/μg endotoxin, tested
• 色: white
• UniProtアクセッション番号: Q58NA1
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: Toxoplasma gondii ... PRF(7900190)

詳細

生物化学的／生理学的作用

Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.

物理的形状

凍結乾燥品(PBS)。

再構成

Reconstitute with 100 μL deionized water.

その他情報

Recombinant profilin (Toxoplasma gondii) (aa 1-163).

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable