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由来生物
human
リコンビナント
expressed in HEK 293 cells
タグ
6-His tagged (C-terminus)
アッセイ
≥95% (SDS-PAGE)
フォーム
lyophilized
分子量
calculated mol wt 45 kDa
observed mol wt 60-90 kDa (DTT-reduced. Cys 32 is the predicted N-terminal.)
包装
pkg of 10 and 50 μg
不純物
<1 EU/μg endotoxin (LAL test)
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... NTRK2(4915)
詳細
The NTRK2 (neurotrophic tyrosine kinase receptor type 2) gene is mapped to human chromosome 9q21.33 and is predominantly expressed in subcutaneous fat and also expressed in visceral fat. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”.
生物化学的／生理学的作用
Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is an oncogenic receptor tyrosine kinase. Abnormal expression of the NTRK2 gene is associated with several cancers including colorectal, breast and papillary thyroid cancer, lung adenocarcinoma and oral squamous cell carcinoma. NTRK2 also known as tropomyosin-related kinase B (TRKB) and is activated by binding of a number of neurotrophins including brain-derived neurotrophic factor(BDNF), neurotrophin 3 (NT-3) and neurotrophic ⅘ (NT-4/5). NTRK2 is involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.
物理的形状
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
再構成
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6473-10UG:
SRP6473-50UG:
最新バージョンのいずれかを選択してください：
The receptor tyrosine kinase ROR1?an oncofetal antigen for targeted cancer therapy.
Hojjat-Farsangi M, et al.
Seminars in Cancer Biology, 29, 21-31 (2014)
A new aspect of the TrkB signaling pathway in neural plasticity.
Ohira K and Hayashi M
Current Neuropharmacology, 7(4), 276-285 (2009)
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF ?/? mouse model of amyotrophic lateral sclerosis.
Brockington A, et al.
BMC Genomics, 11(1), 203-203 (2010)
Transplantation of adipose tissue and stem cells: role in metabolism and disease.
Tran T T and Kahn C R
Nature reviews. Endocrinology, 6(4), 195-195 (2010)
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