SML3350

Acriflavine purified

≥95% (HPLC)

• 別名: Mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinehydrochloride) and proflavine (3,6-diaminoacridine) hydrochloride
• 化学式: [C₁₃H₁₁N₃.HCl]x·[C₁₄H₁₃N₃.HCl]y ·[C₁₄H₁₄N₃·Cl]z
• UNSPSCコード: 12352200
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 色: red to brown
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: NC1=CC2=C(C=C1)C=C3C=CC(N)=CC3=N2.NC4=CC5=C(C=C4)C=C6C=CC(NC)=CC6=N5.NC7=CC8=C(C=C7)C=C9C=CC(N)=CC9=[N+]8C.[Cl-].Cl.Cl

詳細

生物化学的／生理学的作用

Acriflavine is an antimicrobial drug used to treat against sleeping sickness, urinary tract infections, and gonorrhea. Acriflavine is a potent inhibitor of SARS-CoV-2 papain-5 like protease (PLpro), which potently inhibits viral replication in vivo in mice and ex vivo in human airway epithelia. It is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine). Apparently commercial acriflavine mixtures contain the combination of differently methylated proflavines to optimally block the PLpro active site. Also, it potently inhibits replication of other betacoronaviruses.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable