SML3169

NR162

≥98% (HPLC)

• 別名: 4-(Cyclopentylamino)-2-(2,5-dibromo-4-methylbenzylamino)-N-(3-(2-oxooxazolidin-3-yl)propyl)pyrimidine-5-carboxamide
• 実験式（ヒル表記法）: C₂₄H₃₀Br₂N₆O₃
• 分子量: 610.34
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C

詳細

生物化学的／生理学的作用

NR162 is a potent and selective (per DiscoverX KINOMEScan) inhibitor against the calcium/calmodulin-dependent serine protein kinase CASK (Kd = 22 nM by ITC; IC50 = 80 nM by NanoBRET) with much reduced or little potency against other kinases tested (IC50 = 3.8 μM/TYRO3, 18.2 μM/ERBB3, >20 μM/ABL1, AURKC, RPS6KA6, PIKFYVE, RPS6KA5, LRRK2, STK38L by NanoBRET).

Potent and selective inhibitor against the calcium/calmodulin-dependent serine protein kinase CASK.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable