475944

Myeloperoxidase Inhibitor-I

The Myeloperoxidase Inhibitor-I, also referenced under CAS 5351-17-7, controls the biological activity of Myeloperoxidase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 別名: Myeloperoxidase Inhibitor-I
• 実験式（ヒル表記法）: C₇H₉N₃O
• CAS番号: 5351-17-7
• 分子量: 151.17
• MDL番号: MFCD00007606
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: beige
• 溶解性: DMSO: 10 mg/mL; dilute acid: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
• InChI Key: WPBZMCGPFHZRHJ-UHFFFAOYSA-N

詳細

詳細

A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.

A benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC₅₀ = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC₅₀ = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H₂O₂-treated HL-60 promyelocytic leukemia cells.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Myeloperoxidase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM against myeloperoxidase (MPO)

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Engelmann, I., et al. 2000. Redox Report5, 207.
Wagner, B.A., et al. 2000. J. Biol. Chem.275, 22461.
Burner, U., et al. 1999. J. Biol. Chem.274, 9494.
Kettle, A.J., et al. 1997. Biochem. J.321, 503.
Kettle, A.J., et al. 1995. Biochem. J.308, 559.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable