SML2690
Pyridostatin hydrochloride
≥98% (HPLC), powder, G-quadruplex DNA stabilizing agent
別名:
4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide hydrochloride, 4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide hydrochloride, RR 82 HCl, RR-82 HCl, RR82 HCl
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About This Item
実験式（ヒル表記法）:
C31H32N8O5 · xHCl
分子量:
596.64 (free base basis)
MDL番号:
UNSPSCコード:
12352200
NACRES:
NA.77
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製品名
Pyridostatin hydrochloride, ≥98% (HPLC)
アッセイ
≥98% (HPLC)
フォーム
powder
保管条件
desiccated
色
white to beige
溶解性
DMSO: 2 mg/mL, clear
保管温度
2-8°C
アプリケーション
Pyridostatin hydrochloride has been used as a G-quadruplex (G4)-stabilizing ligand to check the effect of G4s on fork progression. It has also been used as a G4-stabilizing ligand to study the effect of G4 on apurinic/apyrimidinic endonuclease 1 (APE1) mediated Kirsten rat sarcoma virus (KRAS) expression in pancreatic ductal adenocarcinoma (PDAC) cell lines.
生物化学的／生理学的作用
Pyridostatin is a highly selective G-quadruplex (G4) interacting molecule. It retards the growth of human cancer cells by inducing replication/transcription dependent on DNA damage. Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G4, inducing DNA damage and cell-cycle arrest.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SML2690-25MG:
SML2690-BULK:
SML2690-VAR:
Z743346-BULK:
Z743346-1000EA:
SML2690-5MG:
最新バージョンのいずれかを選択してください：
Hong-Liang Bao et al.
Nature protocols, 13(4), 652-665 (2018-03-09)
Growing evidence indicates that RNA G-quadruplexes have important roles in various processes such as transcription, translation, regulation of telomere length, and formation of telomeric heterochromatin. Investigation of RNA G-quadruplex structures associated with biological events is therefore essential to understanding the
Alessio De Magis et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(3), 816-825 (2018-12-29)
G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic nuclear processes and trigger DNA damage, genome instability, and cell killing. By different technical approaches, we here establish that specific G4 ligands stabilize G4s and simultaneously
Claudia Ribeiro de Almeida et al.
Molecular cell, 70(4), 650-662 (2018-05-08)
Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we now show that they also form
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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