613560

TMPyP4

≥90% (TLC), solid, telomerase inhibitor, Calbiochem^®

• 別名: TMPyP4, meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate
• 実験式（ヒル表記法）: C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄
• CAS番号: 36951-72-1
• 分子量: 1363.60
• MDL番号: MFCD00013468
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).
• 品質水準: 100
• アッセイ: ≥90% (TLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: purple
• 溶解性: water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3
• InChI Key: AKZFRMNXBLFDNN-UHFFFAOYSA-K

詳細

詳細

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 6.5 µM inhibiting human telomerase

警告

Toxicity: Standard Handling (A)

その他情報

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable