SML2430

Kdo2-Lipid A (KLA)

≥90% (HPLC)

• 別名: Di[3-deoxy-D-manno-octulosonyl]-lipid A (ammonium salt), KLA, Kdo2-LipidA
• 実験式（ヒル表記法）: C₁₁₀H₂₀₂N₂O₃₉P₂ · xNH₃
• CAS番号: 1246298-62-3
• 分子量: 2238.72 (free acid basis)
• UNSPSCコード: 12352211
• NACRES: NA.77

特性

• 由来生物: Escherichia coli
• アッセイ: ≥90% (HPLC)
• フォーム: solid
• 保管温度: −20°C
• SMILES記法: O=C(O)[C@@]1(O[C@H]2[C@@H](O)C([C@H](O)CO)O[C@](C(O)=O)(OC[C@H]3O[C@@H](OC[C@H]4O[C@H](OP(O)(O)=O)[C@@H](NC(C[C@@H](CCCCCCCCCCC)O)=O)C(OC(C[C@@H](CCCCCCCCCCC)O)=O)[C@H]4O)C(NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCCCC)=O)=O)[C@@H](OC(C[C@@H](CCCCCCCCCCC)OC(CCCCC

詳細

詳細

3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.

その他情報

Solubility: Kdo2 -Lipid A can be dissolved in a solution of 0.1-0.5% Triethylamine (Sigma Cat# 90335) at 1 mg/ml (In case of percipitation use sonication). Use sonication to directly solublized in cell culture medium. Storage: Once Kdo2-lipidA is dissolved in 0.1-0.5% Triethylamine (Sigma Cat# 90335) aliquot and store at -20°C. The solution is stable for 2 months in -20°C.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): No data available
• 引火点(℃): No data available