SML2392

DREADD Agonist 21 dihydrochloride

≥98% (HPLC), powder, DREADD agonist

• 別名: 11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride
• 実験式（ヒル表記法）: C₁₇H₁₈N₄ · 2HCl
• CAS番号: 56296-18-5
• 分子量: 351.27
• MDL番号: MFCD25121806
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: yellow to brown
• 溶解性: H₂O: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

詳細

生物化学的／生理学的作用

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable