SML1681

Endosidin2

≥98% (HPLC)

• 別名: (E)-3-Fluoro-N′-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide
• 実験式（ヒル表記法）: C₁₅H₁₂FIN₂O₃
• CAS番号: 1839524-44-5
• 分子量: 414.17
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826011
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: FC1=CC(C(N/N=C/C2=CC(OC)=C(O)C(I)=C2)=O)=CC=C1
• InChI: 1S/C15H12FIN2O3/c1-22-13-6-9(5-12(17)14(13)20)8-18-19-15(21)10-3-2-4-11(16)7-10/h2-8,20H,1H3,(H,19,21)/b18-8+
• InChI Key: UIADDCURKKFTFW-QGMBQPNBSA-N

詳細

生物化学的／生理学的作用

Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd = 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.  

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable