673000

Vacuolin-1

≥95% (HPLC), solid, lysosome inhibitor, Calbiochem^®

• 別名: Vacuolin-1
• 実験式（ヒル表記法）: C₂₆H₂₄IN₇O
• CAS番号: 351986-85-1
• 分子量: 577.42
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Vacuolin-1, A cell-permeable triazine based compound that inhibits Ca²⁺-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles.
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 25 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C26H24IN7O/c27-21-9-7-8-20(18-21)19-28-32-24-29-25(33-14-16-35-17-15-33)31-26(30-24)34(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-13,18-19H,14-17H2,(H,29,30,31,32)/b28-19+
• InChI Key: JMEJTSRAQUFNOP-TURZUDJPSA-N

詳細

詳細

A cell-permeable triazine based compound that inhibits Ca²⁺-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles. It does not disturb the organization of the actin or tubulin cytoskeletal network, nor does it interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.

A cell-permeable triazine-based compound that inhibits Ca²⁺-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding. Does not affect the resealing process and the exocytosis of enlargeosomes. It also does not disturb the organization of the actin or tubulin cytoskeletal network or interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Ca2+-dependent fusion of lysosomes with the plasma membrane

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable