SML1578

Aftin-4

≥98% (HPLC)

• 別名: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, Amyloid-β Forty-Two Inducer 4, N6-Methyl-(R)-roscovitine
• 実験式（ヒル表記法）: C₂₀H₂₈N₆O
• CAS番号: 866893-90-5
• 分子量: 368.48
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: protect from light
• 色: white to beige
• 溶解性: DMSO: 25 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: [n]1(c2nc(nc(c2nc1)N(Cc3ccccc3)C)N[C@@H](CO)CC)C(C)C
• InChI: 1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
• InChI Key: YPYWONAECUVKHY-MRXNPFEDSA-N

詳細

生物化学的／生理学的作用

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3