SML0846

Anagrelide hydrochloride

≥98% (HPLC)

• 別名: 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2(3H)-one hydrochloride
• 実験式（ヒル表記法）: C₁₀H₇Cl₂N₃O · HCl
• CAS番号: 58579-51-4
• 分子量: 292.55
• UNSPSCコード: 41106305
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 1 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• InChI: 1S/C10H7Cl2N3O.ClH/c11-6-1-2-7-5(9(6)12)3-15-4-8(16)14-10(15)13-7;/h1-2H,3-4H2,(H,13,14,16);1H
• InChI Key: TVWRQCIPWUCNMI-UHFFFAOYSA-N

詳細

詳細

Download the CofA, SDS and IFU specific to your product lot and format
Fab fragments from polyclonal anti-fluorescein antibodies, conjugated to alkaline phosphatase.
After immunization with fluorescein, the sheep IgG was purified by ion exchange chromatography and the specific IgG was isolated by immunosorption. The Fab fragments obtained by papain digestion were purified by gel filtration, conjugated with alkaline phosphatase, and stabilized in 50 mM triethanolamine buffer, 3 M NaCl, 1 mM MgCl₂, 0.1 mM ZnCl₂, 1% bovine serum albumin (w/v), pH 7.6.
Clone: polyclonal
Ig class: sheep IgG, Fab fragments

Anagrelide belongs to the imidazo[2,1-b]quinazolin-2-one series of compounds.

生物化学的／生理学的作用

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity (IC₅₀ = 36 nM for inhibition of phosphodiesterase-III). Anagrelide inhibits the maturation of megakaryocytes into platelets, reducing both megakaryocyte hyperproliferation and differentiation. As a drug, anagrelide is antithrombocythemic used for the treatment of overproduction of blood platelets.

Anagrelide is a phosphodiesterase inhibitor with antiplatelet activity.

In human and animals, anagrelide has an inhibitory effect on platelet aggregation. Small doses of anagrelide can generate thrombocytopenia. Anagrelide is not advised during pregnancy. It is effectively used in the treatment of essential thrombocytosis.

特徴および利点

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H351,H361d,H413
• 注意書き: P202 - P273 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Aquatic Chronic 4 - Carc. 2 - Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable