N1530

ノミフェンシン マレイン酸塩

• 別名: 1,2,3,4-テトラヒドロ-2-メチル-4-フェニル-8-イソキノリンアミン マレイン酸塩
• 実験式（ヒル表記法）: C₁₆H₁₈N₂ · C₄H₄O₄
• CAS番号: 32795-47-4
• 分子量: 354.40
• EC Number: 251-223-7
• MDL番号: MFCD00069320
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277920
• NACRES: NA.77

特性

• フォーム: powder
• 品質水準: 200
• SMILES記法: [H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CC(c2ccccc2)c3cccc(N)c3C1
• InChI: 1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI Key: GEOCVSMCLVIOEV-BTJKTKAUSA-N
• 遺伝子情報: human ... DBH(1621) , SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

詳細

アプリケーション

Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.

生物化学的／生理学的作用

Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.

特徴および利点

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319,H335
• 注意書き: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves