SML0553

NN414

≥98% (HPLC)

• 別名: 6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide, Tifenazoxide
• 実験式（ヒル表記法）: C₉H₁₀ClN₃O₂S₂
• CAS番号: 279215-43-9
• 分子量: 291.78
• MDL番号: MFCD18711369
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825549
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 15 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: CC1(CC1)NC2=NS(=O)(=O)c3sc(Cl)cc3N2
• InChI: 1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13)
• InChI Key: KYSFUHHFTIGRJN-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. Activation of the pancreatic Kir6.2/SUR KATP channels inhibits insulin release to induce beta cell rest, reducing the workload of the beta cell which is thought may prove beneficial for patients with type 2 diabetes. A recent study found that NN414 also triggered burst-like discharges in substantia nigra dopamine neurons. These K-ATP channel enabled burst-like discharges are associated with novelty-dependent exploratory behavior and may also have relevance to Parkinson′s disease.

特徴および利点

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable