SML0140

BV02

≥98% (HPLC)

• 別名: 2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid
• 実験式（ヒル表記法）: C₂₀H₁₅N₃O₅
• CAS番号: 292870-53-2
• 分子量: 377.35
• MDL番号: MFCD00356631
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825188
• NACRES: NA.77

特性

• 詳細: The structure of BV02 differs slightly from the published form, but has been internally verified by Sigma-Aldrich quality control.
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to off-white
• 溶解性: DMSO: >5 mg/mL
• 保管温度: room temp
• SMILES記法: CN1N(c2ccccc2)C(=O)C(N3C(=O)c4ccc(cc4C3=O)C(O)=O)=C1C
• InChI: 1S/C20H15N3O5/c1-11-16(19(26)23(21(11)2)13-6-4-3-5-7-13)22-17(24)14-9-8-12(20(27)28)10-15(14)18(22)25/h3-10H,1-2H3,(H,27,28)
• InChI Key: ZFYSDSINNOLWGO-UHFFFAOYSA-N

詳細

アプリケーション

BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma.

BV02, an inhibitor of the 14-3-3 scaffolding protein docking sites, may be used to study the roles and functions of 14-3-3 scaffolding proteins in signaling pathways involved in the cell cycle, and processes such as apoptosis, stress response, and malignant cell transformation.

生物化学的／生理学的作用

BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.

安全性情報

• ピクトグラム: GHS09
• シグナルワード: Warning
• 危険有害性情報: H400
• 注意書き: P273 - P391 - P501
• 危険有害性の分類: Aquatic Acute 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable