SML1466

ABH hydrochloride

≥98% (HPLC)

• 別名: 2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
• 実験式（ヒル表記法）: C₆H₁₄BNO₄ · HCl
• CAS番号: 194656-75-2
• 分子量: 211.45
• MDL番号: MFCD22887376
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825900
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D +8 to +13°, c = 0.7 in H₂O
• 保管条件: desiccated
• 色: white to beige
• 溶解性: H₂O: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
• InChI: 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
• InChI Key: XCUVEZUCSHVMRK-JEDNCBNOSA-N

詳細

生物化学的／生理学的作用

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable