SMB01055

Colladin

≥90% (LC/MS-ELSD)

• 別名: Coladin
• 実験式（ヒル表記法）: C₂₆H₃₂O₅
• CAS番号: 28691-96-5
• 分子量: 424.53
• UNSPSCコード: 12352205
• NACRES: NA.25

特性

• 由来生物: plant
• アッセイ: ≥90% (LC/MS-ELSD)
• 形状: solid
• 分子量: 424.53
• 溶解性: water: slightly soluble
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• 保管温度: −20°C

詳細

詳細

Colladin, a sesquiterpenoid coumarin, is a natural product commonly available from Ferula Sp. (F. arrigonii, F. vesceritensis, F. campestris and F. sinaica) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including anticancer, neuroprotective, and antiglaucoma properties.

アプリケーション

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

生物化学的／生理学的作用

According to the existing research, Coladin exhibited notable anti-cancer properties by substantially reducing cell proliferation and mitochondrial dehydrogenase activity in mouse B16F1 melanoma cells. These effects induced apoptosis through mechanisms involving decreased mitochondrial membrane potential and mitochondrial respiratory rate, underscoring its potential as a natural anti-cancer agent. Isolated from the roots of Ferulago campestris, coladin, along with other compounds such as umbelliprenin and epielmanticine, displayed inhibitory activity against Acetylcholinesterase (AChE) with an IC50 of 0.1 mM, suggesting its potential application in the treatment of neurological disorders like Alzheimer′s disease. Coladin, identified as one of the constituents in Heptaptera triquetra fruit, exhibited remarkable inhibitory activity against acetylcholinesterase (AChE), human carbonic anhydrase isoenzyme (hCA) I, and hCA II, with IC50 values of 8.25 nM, 28.90 nM, and 43.31 nM, respectively. This highlights its potential in the development of phytotherapeutics for conditions like Alzheimer′s disease (AD) and glaucoma.

特徴および利点

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable