SMB00579

Tacalcitol

≥99% (HPLC)

• 別名: (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D₃
• 実験式（ヒル表記法）: C₂₇H₄₄O₃
• CAS番号: 57333-96-7
• 分子量: 416.64
• MDL番号: MFCD00866623
• UNSPSCコード: 12352205
• PubChem Substance ID: 329825068
• NACRES: NA.79

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥99% (HPLC)
• フォーム: powder
• テクニック: HPLC: suitable
• 色: white to off-white
• 保管温度: −20°C
• SMILES記法: C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C
• InChI: 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
• InChI Key: BJYLYJCXYAMOFT-RSFVBTMBSA-N

詳細

詳細

Tacalcitol is a synthetic vitamin D₃ analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.

生物化学的／生理学的作用

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P301 + P330 + P331 + P310
• 危険有害性の分類: Acute Tox. 1 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable