SAB4300135

Anti-phospho-PAK1/PAK2/PAK3 (pThr⁴²³/pThr⁴⁰²/pThr⁴²¹) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-ADE2 antibody produced in rabbit, Anti-CDKN1A antibody produced in rabbit, Anti-PAK65 antibody produced in rabbit
• MDL番号: MFCD02097133
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: 61-67 kDa; 68-74 kDa
• 交差性: mouse, human, rat
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• アイソタイプ: IgG
• 免疫原配列: (R-S-TP-M-V)
• NCBIアクセッション番号: NP_001121638.1; NP_001122092.1; NP_002568.2
• UniProtアクセッション番号: Q13177
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr423/pThr402/pThr421)
• 遺伝子情報: human ... PAK1(5058) , PAK2(5062) , PAK3(5063)

詳細

免疫原

Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3.

特徴および利点

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ターゲットの説明

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable