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由来生物
mouse
抗体製品の状態
purified from hybridoma cell culture
抗体製品タイプ
primary antibodies
クローン
WH-3, monoclonal
形状
buffered aqueous solution
分子量
antigen ~55 kDa
化学種の反応性
mouse, human, rabbit, sheep, rat
濃度
~1.0 mg/mL
テクニック
immunoblotting: 2-4 μg/mL using rabbit pineal gland lysate
immunofluorescence: suitable
immunohistochemistry: suitable
アイソタイプ
IgG3
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
詳細
Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the WH-3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with recombinant rabbit Tryptophan Hydroxylase. Tryptophan Hydroxylase (TPH), also known as TpOH, TrpH or L-tryptophan tetrahydropteridine: oxygen oxidoreductase (EC 1.14.16.4) is a member of biopterin-dependent aromatic amino acid hydroxylases family, together with tyrosine hydroxylase and phenylalanine hydroxylase. This gene spanning 29kbp with 11 exons is mapped to human chromosome 11p15.3-p14. This 444 amino acid protein is expressed in the gut, spleen, thymus and also in the pineal gland and the pituitary.
免疫原
recombinant rabbit Tryptophan Hydroxylase.
アプリケーション
Anti-Tryptophan Hydroxylase antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunohistochemistry
- immunofluorescence
生物化学的／生理学的作用
Tryptophan Hydroxylase (TPH) is a rate-limiting tetramer enzyme in the synthetic pathway of neurotransmitter serotonin from L-tryptophan and is considered a key factor for the maintenance of normal serotonin transmission in the central nervous system. The tryptophan hydroxylase 1 gene (TPH1) catalyzes the synthesis of 5-hydroxytryptophan. Mutation in the TPH1 gene leads to schizophrenia, irritable bowel syndrome (IBS) in women, suicidal behavior and depressive disorders.The encoded protein plays a vital role in regulation of cardiovascular function.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200723-100UL:
SAB4200723-VAR:
SAB4200723-BULK:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey
Xu J, et al.
Genes, 10(3), 203-203 (2019)
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
Cote F, et al.
Proceedings of the National Academy of Sciences of the USA, 100(23), 13525-13530 (2003)
The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: A multi-centre case-control study and meta-analysis
Saetre P, et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 153(2), 387-396 (2010)
TPH1 A218C polymorphism and temperament in major depression
Andre K, et al.
BMC Psychiatry, 13(1), 118-118 (2013)
Characterization of a stable form of tryptophan hydroxylase from the human parasite Schistosoma mansoni
Hamdan FF and Ribeiro P
The Journal of Biological Chemistry, 274(31), 21746-21754 (1999)
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