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由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified from hybridoma cell culture
抗体製品タイプ
primary antibodies
クローン
4A4, monoclonal
フォーム
buffered aqueous solution
分子量
antigen ~72 kDa
化学種の反応性
human
強化検証
independent
Learn more about Antibody Enhanced Validation
濃度
~1.0 mg/mL
テクニック
indirect immunofluorescence: 0.25-0.5 μg/mL using human HeLa cells
western blot: 0.25-0.5 μg/mL using whole extracts of human HeLa cells
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... LMNA(4000)
詳細
Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.
免疫原
synthetic peptide corresponding to the C-terminus of mature human Lamin A.
アプリケーション
Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.
生物化学的／生理学的作用
Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease
Fatkin D
The New England Journal of Medicine, 341, 1715-1724 (1999)
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy.
Cao H and Hegele RA
Human Molecular Genetics, 9, 109-112 (2000)
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome.
Eriksson M
Nature, 423, 293-298 (2003)
Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study.
Ollila L
Clinical Physiology and Functional Imaging, 37, 8-16 (2017)
Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.
Kaspi E
PLoS ONE, 12 (2017)
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