SAB4200151

抗ドローシャ抗体 ウサギ宿主抗体

~1.0 mg/mL, affinity isolated antibody

• 別名: Anti-ETOHI2, RANSE3L, Anti-RN3, Anti-RNASEN, Anti-RNC, Anti-RNase III, Anti-p241, Anti-ribonuclease type III, nuclear
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 130-160 kDa
• 化学種の反応性: human
• 濃度: ~1.0 mg/mL
• テクニック: indirect immunofluorescence: 2.5-5 μg/mL using paraformaldehyde fixed HEK-293T cells.; western blot: 2-4 μg/mL using HeLa nuclear cell lysates.
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... RNASEN(29102)

詳細

詳細

Drosha ribonuclease III (Drosha) is encoded by the gene mapped to human chromosome 5p13.3. It is a double-stranded RNA (dsRNA)-specific RNase III enzyme. The encoded protein contains RNase III domains (RIIIDs) on the top and central domain (CED) at the bottom. In addition, it also contains unique non-canonical zinc-finger motifs.

アプリケーション

Anti-Drosha antibody produced in rabbit has been used in western blotting and immunofluorescence.

生物化学的／生理学的作用

Drosha ribonuclease III (Drosha) plays a vital role in initiation of microRNA (miRNA) maturation. It catalyzes the cleavage of stem loop structure from the primary microRNA (pri-miRNA).Drosha ribonuclease III (Drosha) plays a vital role in initiation of microRNA (miRNA) maturation. It catalyzes the cleavage of stem loop structure from the primary microRNA (pri-miRNA). Mutation in the gene is associated with development of Epithelial ovarian cancer (EOC). Knockdown of Drosha can enhance the sensitivity of gastric cancer to epirubicin.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable