P9246

PB28 dihydrochloride

≥98% (HPLC), solid

• 別名: 1-Cyclohexyl-4-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl)piperazine dihydrochloride
• 化学式: C₂₄H₄₀Cl₂N₂O
• CAS番号: 172906-90-0
• 分子量: 443.49
• MDL番号: MFCD06798349
• UNSPSCコード: 12352200
• PubChem Substance ID: 329820345
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: desiccated
• 色: white
• 溶解性: H₂O: ~10 mg/mL at 60 °C
• SMILES記法: Cl[H].Cl[H].COc1cccc2C(CCCN3CCN(CC3)C4CCCCC4)CCCc12
• InChI: 1S/C24H38N2O.2ClH/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21;;/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3;2*1H
• InChI Key: DSRBJOQIBXACIV-UHFFFAOYSA-N

詳細

アプリケーション

PB28 dihydrochloride has been used to test its inhibitory effect on potassium voltage-gated channel, shab-related subfamily, member 1, Kv2.1.

生物化学的／生理学的作用

PB28, a cyclohexylpiperazine derivative, is a sigma 1 (σ1)-R antagonist. It elicits anti-tumor activity in breast, ovarian and colorectal cancer cell lines.

Selective σ₂ opioid receptor ligand; putative σ₂ agonist

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves