P8232

抗P2X₇レセプター抗体 ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: Anti-P2X₇ Antibody, P2X₇ Receptor Detection, Rabbit Anti-P2X₇
• MDL番号: MFCD02097118
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: lyophilized powder
• 交差性: human, mouse, rat
• テクニック: immunohistochemistry: suitable; western blot: 1:200-1:1,000
• UniProtアクセッション番号: Q99572
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... P2RX7(5027) ; mouse ... P2rx7(18439) ; rat ... P2rx7(29665)

詳細

詳細

Purinergic receptor P2X₇ is an ATP-gated cation channel. It is expressed in retinal pigmented epithelium and neural retina. The gene encoding this protein is localized on human chromosome 12.

免疫原

ラットP2X₇のアミノ酸576-595 (N末端システイン付加) に相当するペプチド。このエピト-プはマウスおよびヒトP2X₇で高度に保存されています。

アプリケーション

Anti-P2X7 Purinergic Receptor antibody produced in rabbit has been used in

• immunoprecipitation
• immunofluorescence and confocal microscopy
• western blotting

生物化学的／生理学的作用

Purinergic receptor P2X₇ has a role in immunological processes. It has a role during oxidative stress under pathological conditions. The channel is permeable to Na⁺, Ca²⁺ and K⁺. Prolonged activation of the channel under some pathological conditions leads to the passage of large molecules and ultimately cell death. P2X7 may be involved in the release of interleukin-1β (IL-1β) and indirectly initiate an inflammatory cascade.

物理的形状

凍結乾燥品(PBS, pH 7.4, 1% BSA, 0.05%アジ化ナトリウム含有)。

保管および安定性

Prior to reconstitution, store at –20°C. After reconstitution, the stock antibody solution may be stored at 2–8°C for up to two weeks. For extended storage, freeze at -20°C, or below, in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. Centrifuge all antibody preparations before use (10,000 x g 5 min). Working dilution samples should be discarded if not used within 12 hours.

その他情報

In order to obtain the best results using various techniques and preparations, we recommend determining the optimal working dilutions by titration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable