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形状
powder
品質水準
オーガナイザー
Watson
SMILES記法
OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
InChI
1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI Key
JXYWFNAQESKDNC-BTJKTKAUSA-N
遺伝子情報
human ... HRH1(3269)
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アプリケーション
Pyrilamine maleate salt has been used:
- to treat Cassiopea sp. as H1 receptor antagonist
- to intraperitoneally inject mice to prevent the release of endogenous histamine
- in membrane binding assay to determine the Ki values and in the comparative inhibitory concentration (IC50) studies by whole-cell patch clamp technique
生物化学的/生理学的作用
Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.
特徴および利点
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
関連製品
シグナルワード
Warning
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
試験成績書(COA)
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The [3H] dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+] o
Journal of Pharmacological and Toxicological Methods, 50(3), 187-199 (2004)
Physical and biological properties of pyrilamine.
Journal of pharmaceutical sciences, 72(1), 3-12 (1983-01-01)
Synapse (New York, N.Y.), 32(4), 301-311 (1999-05-20)
Various effects of chlorpheniramine (CPA), diphenhydramine (DIPH), tripelennamine (TRIP), and pyrilamine (PYRI) on fenfluramine (FEN)-induced depletion of serotonin in the brain of rats were observed to be dependent on body temperature. Levels of 5-HT and 5-HIAA in the frontal cortex
The jellyfish Cassiopea exhibits a sleep-like state
Current Biology, 27(19), 2984-2990 (2017)
Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
Journal of Visualized Experiments, 27(136), e57524-e57524 (2018)
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