P3076

血小板由来成長因子-AA ヒト

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 別名: PDGF−AA
• MDL番号: MFCD00081862
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 製品名: 血小板由来成長因子-AA ヒト, PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 由来生物: human
• 品質水準: 100
• リコンビナント: expressed in E. coli
• アッセイ: ≥98% (SDS-PAGE and HPLC)
• フォーム: lyophilized powder
• 有効性: 1.0-3.0 ng/mL ED₅₀
• 品質: endotoxin tested
• 分子量: 28.5 kDa (containing 250 amino acid residues)
• 包装: pkg of 10 μg; pkg of 50 μg
• 保管条件: avoid repeated freeze/thaw cycles
• テクニック: cell culture | mammalian: suitable
• 不純物: <1 EU/μg
• UniProtアクセッション番号: P04085
• 保管温度: −20°C
• 遺伝子情報: human ... PDGFRA(5154)

詳細

詳細

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

生物化学的／生理学的作用

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

その他情報

ヒトPDGFのA鎖からなるホモ二量体

物理的形状

滅菌濾過したバッファ-で調製した溶液の凍結乾燥品

アナリシスノート

生物活性は、BALB/c 3T3細胞のthymidine取り込みに対する用量依存的な促進活性として測定されています。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable