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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~31 kDa
化学種の反応性
human
テクニック
western blot: 1:500-1:2,000
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... OTUB1(55611)
詳細
OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1), a deubiquitinating enzyme (DUB) is a member of the ovarian tumor (OTU) domain protease superfamily. It is expressed in kidney, intestine, brain, liver and lung. This gene is located on human chromosome 11q13.1.
免疫原
synthetic peptide corresponding to amino acids 57-70 of human OTUB1
アプリケーション
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生物化学的/生理学的作用
OTUB1 (OTU domain-containing ubiquitin aldehyde binding protein 1) expression helps to predict the prognosis of hepatocellular carcinoma (HCC) in patients. It can control the T-cell anergy by improving the degradation of the E3 ligase gene related to anergy in lymphocytes (GRAIL).
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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最新バージョンのいずれかを選択してください:
Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion
Acta biochimica et biophysica Sinica, 49(8) (2017)
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination
EMBO Molecular Medicine, 8(3) (2016)
Colon cancer bears overexpression of OTUB1
Pathology Research and Practice, 210(11) (2014)
Nature, 466(7309), 941-946 (2010-08-21)
DNA double-strand breaks (DSBs) pose a potent threat to genome integrity. These lesions also contribute to the efficacy of radiotherapy and many cancer chemotherapeutics. DSBs elicit a signalling cascade that modifies the chromatin surrounding the break, first by ATM-dependent phosphorylation
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