N2001

臭化ネオスチグミン

≥98% (HPLC and titration), powder

• 別名: 3-(N,N-ジメチルカルバモイロキシ)-N,N,N,-トリメチルアニリニウム ブロミド, プロスチグミン
• 実験式（ヒル表記法）: C₁₂H₁₉BrN₂O₂
• CAS番号: 114-80-7
• 分子量: 303.20
• EC Number: 204-054-8
• MDL番号: MFCD00011795
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277854
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC and titration)
• フォーム: powder
• 色: white
• mp: 175-177 °C (lit.)
• 溶解性: H₂O: 1 g/mL; ethanol: soluble
• SMILES記法: [Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
• InChI: 1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
• InChI Key: LULNWZDBKTWDGK-UHFFFAOYSA-M
• 遺伝子情報: human ... ACHE(43)

詳細

アプリケーション

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

• to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
• to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
• to study its effects on depolarization of bag cell neurons.

生物化学的／生理学的作用

アセチルコリンエステラ-ゼの可逆的阻害剤で、エセリンとほぼ同じですが、血液脳関門は通過しません。

アセチルコリンエステラ-ゼの可逆的阻害剤で、血液脳関門は通過しません。

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

特徴および利点

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H300 + H310 + H330,H315,H317,H319,H334,H335
• 注意書き: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges