M7317

Monoclonal Anti-MDR3 P-Glycoprotein antibody produced in mouse

250 μg/mL, clone P₃II-26, tissue culture supernatant

• 別名: Anti-ABC21, Anti-GBD1, Anti-ICP3, Anti-MDR2, Anti-MDR2/3, Anti-MDR3, Anti-PFIC-3, Anti-PGY3
• MDL番号: MFCD03791722
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: tissue culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: P₃II-26, monoclonal
• 化学種の反応性: human
• 濃度: 250 μg/mL
• テクニック: immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues); immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections; western blot: suitable
• アイソタイプ: IgG2b
• UniProtアクセッション番号: P21439
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ABCB11(8647) , ABCB4(5244)

詳細

詳細

Multidrug resistance protein 3 (MDR3) is also known as ATP binding cassette subfamily B member 4. It is expressed in hepatocytes and made up of 1279 amino acids. The gene encoding it is localized on human chromosome 7q21.12 and consists of 27 exons.

特異性

Reacts with an internal epitope of MDR3. Does not cross-react with human MDR1 P-gp.

免疫原

MDR3 P-gp (amino acids 629-692) GST fusion protein.

生物化学的／生理学的作用

Multidrug resistance protein 3 (MDR3) acts as an ATP-dependent exporter and transfers phospholipids, particularly phosphatidylcholine (PC), into bile. Dysfunctioning of MDR3 leads to excess of bile salts in primary bile and further leads to liver diseases.

物理的形状

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable