M0195

MAPKAPK2 ヒト

recombinant, expressed in HEK 293 cells, ≥60 units/mg protein, buffered aqueous glycerol solution

• 別名: MAPKAPキナーゼ2 ヒト, MAPキナーゼ活性化プロテインキナーゼ2
• MDL番号: MFCD04974881
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• リコンビナント: expressed in HEK 293 cells
• 品質水準: 100
• フォーム: buffered aqueous glycerol solution
• 比活性: ≥60 units/mg protein
• 分子量: 45-60 kDa
• UniProtアクセッション番号: P49137
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... MAPKAPK2(9261)

詳細

生物化学的／生理学的作用

MAPKAPK2 is a serine/threonine protein kinase activated by the p38 MAP kinase in response to various signals including mitogenic and stress stimuli. MAPKAPK2 is distinguished from the RSK family of ribosomal protein S6 kinases (also termed MAPKAPK1), which are activated by the MAP kinases, ERK1, and ERK2 based on its substrate specificity and amino acid sequence. Upon activation, p38 MAP kinase activates the downstream MAPKAPK2 by phosphorylation of the threonine residue in the Pro-Thr motif in response to heat shock or mitogenic stimuli. Activated MAPKAPK2 phosphorylates the small heat shock protein HSP25/HSP27, both in vitro and in vivo, at serine residues. Thus, HSP25/HSP27 seems to be the physiological substrate of MAPKAPK2.

単位の定義

1ユニットは、pH 7.4、30°Cで、1分間に1.0 nmolのリン酸をHSP 25に取り込ませる量です。

物理的形状

Solution in 50 mM Tris-HCl, pH 7.4, 100 mM NaCl, 0.05 mM EDTA, 2 mM DTT, and 10% glycerol.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable