K2644

キスペプチン-234抗体 トリフルオロアセタート塩

≥95% (HPLC)

• 別名: キスペプチン-10ペプチド234抗体
• 実験式（ヒル表記法）: C₆₃H₇₈N₁₈O₁₃ · xC₂HF₃O₂
• CAS番号: 1848962-29-7
• 分子量: 1295.41 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• アッセイ: ≥95% (HPLC)
• 形状: film
• 色: colorless to white
• 溶解性: H₂O: >1 mg/mL
• 保管温度: −20°C

詳細

生物化学的／生理学的作用

Kisspeptin-234 is a 10-amino acid peptide antagonist with potent neutral antagonist activity at GPR-54 and competes directly at the Kisspeptin-10 binding site. Kisspeptin-234 is the first reported antagonist for the kisspeptin-1/GPR-54 signaling system.

Gonadotropin-releasing hormone (GnRH) modulates the hypothalamic-pituitary-gonadal axis, enabling the brain to control reproductive processes. Kisspeptin-1 is a peptide neurotransmitter released from afferent neurons onto GnRH neurons, where it binds to and activates to the orphan receptor GPR-54 to regulate release of GnRH. Regulation of kisspeptin/GPR-54 signaling presents an opportunity for reproductive therapeutics above the level of GnRH and gonadotropin secretion. Pharmacological and selective tools are needed to better understand kisspeptin-1/GPR-54 signaling. Analogs of kisspeptin-10, a 10-amino acid portion of kisspeptin-1, were designed to be full and neutral antagonists of GPR-54.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable